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Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase

The pursuit of antimicrobial drugs that target dihydrofolate reductase (DHFR) exploits differences in sequence and dynamics between the pathogenic and human enzymes. Here, we present five crystal structures of human DHFR bound to a new class of antimicrobial agents, the propargyl-linked antifolates...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Lamb, Kristen M., G-Dayanandan, Narendran, Wright, Dennis L., Anderson, Amy C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855305/
https://ncbi.nlm.nih.gov/pubmed/24053334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400852h
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