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The crystal structure of Candida glabrata dihydrofolate reductase drives new inhibitor design toward efficacious antifungal agents
Candida glabrata is a lethal fungal pathogen resistant to many antifungal agents and has emerged as a critical target for drug discovery. Over the past several years we have been developing a class of propargyl-linked antifolates as new antimicrobials and hypothesized that these compounds could be e...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610858/ https://ncbi.nlm.nih.gov/pubmed/18804036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.07.013 |
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