Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternative Conformation of NADPH that may be Linked to Trimethoprim Resistance

Both hospital- and community-acquired Staphylococcus aureus infections have become major health concerns in terms of morbidity, suffering and cost. Trimethoprim-sulfamethoxazole (TMP-SMZ) is an alternative treatment for methicillin-resistant S. aureus (MRSA) infections. However, TMP-resistant strain...

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Detalhes bibliográficos
Main Authors: Frey, Kathleen M., Liu, Jieying, Lombardo, Michael N., Bolstad, David B., Wright, Dennis L., Anderson, Amy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723953/
https://ncbi.nlm.nih.gov/pubmed/19249312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.02.045
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