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Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors

Candida glabrata, a fungal strain resistant to many commonly administered antifungal agents, has become an emerging threat to human health. In previous work, we validated that the essential enzyme, dihydrofolate reductase (DHFR), is a drug target in C. glabrata. Using a crystal structure of DHFR fro...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Jieying, Bolstad, David B., Smith, Adrienne E., Priestley, Nigel D., Wright, Dennis L., Anderson, Amy C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838185/
https://ncbi.nlm.nih.gov/pubmed/19152636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00745.x
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