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Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors
Candida glabrata, a fungal strain resistant to many commonly administered antifungal agents, has become an emerging threat to human health. In previous work, we validated that the essential enzyme, dihydrofolate reductase (DHFR), is a drug target in C. glabrata. Using a crystal structure of DHFR fro...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838185/ https://ncbi.nlm.nih.gov/pubmed/19152636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00745.x |
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