Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase

Bacillus anthracis, the causative agent of anthrax, poses a significant biodefense danger. Serious limitations in approved therapeutics and the generation of resistance have produced a compelling need for new therapeutic agents against this organism. Bacillus anthracis is known to be insensitive to...

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Bibliographic Details
Main Authors: Beierlein, Jennifer M., Frey, Kathleen M., Bolstad, David B., Pelphrey, Phillip M., Joska, Tammy M., Smith, Adrienne E., Priestley, Nigel D., Wright, Dennis L., Anderson, Amy C.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645930/
https://ncbi.nlm.nih.gov/pubmed/19007108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800776a
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