Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity

Resistance to the antibacterial antifolate trimethoprim (TMP) is increasing in members of the family Enterobacteriaceae, driving the design of next-generation antifolates effective against these Gram-negative pathogens. The propargyl-linked antifolates are potent inhibitors of dihydrofolate reductas...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Lamb, Kristen M., Lombardo, Michael N., Alverson, Jeremy, Priestley, Nigel D., Wright, Dennis L., Anderson, Amy C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249513/
https://ncbi.nlm.nih.gov/pubmed/25288083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03555-14
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