Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes

Por Ichikawa, Tomonaga, Li, Jinqing, Meyer, Colin J., Janicki, Joseph S., Hannink, Mark, Cui, Taixing
Publicado em 2009

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

Por Dinkova-Kostova, Albena T., Baird, Liam, Holmström, Kira M., Meyer, Colin J., Abramov, Andrey Y.
Publicado no Biochem Soc Trans (2015)

The Synthetic Triterpenoid, CDDO-Me, Modulates the Proinflammatory Response to In Vivo Lipopolysaccharide Challenge

Por Auletta, Jeffery J., Alabran, Jennifer L., Kim, Byung-Gyu, Meyer, Colin J., Letterio, John J.
Publicado em 2010

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

Por Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Khazaeli, Mahyar, Yuan, Jun, Meyer, Colin J.
Publicado em 2014

Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

Por Reisman, Scott A., Chertow, Glenn M., Hebbar, Sudarshan, Vaziri, Nosratola D., Ward, Keith W., Meyer, Colin J.
Publicado em 2012

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease()

Por Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Shelkovnikov, Stan, Farzaneh, Seyed H., Khazaeli, Mahyar, Meyer, Colin J.
Publicado em 2013

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

Por Tan, Yi, Ichikawa, Tomonaga, Li, Jinqing, Si, Qiusheng, Yang, Huaitao, Chen, Xiangbai, Goldblatt, Curtis S., Meyer, Colin J., Li, Xiaokun, Cai, Lu, Cui, Taixing
Publicado em 2011

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

Por Reisman, Scott A., Goldsberry, Angela R., Lee, Chun-Yue I., O’Grady, Megan L., Proksch, Joel W., Ward, Keith W., Meyer, Colin J.
Publicado no BMC Dermatol (2015)

The synthetic triterpenoid, RTA405, increases glomerular filtration rate and reduces angiotensin II-induced contraction of glomerular mesangial cells

Por Ding, Yanfeng, Stidham, Rhesa, Bumeister, Ron, Trevino, Isaac, Winters, Ali, Sprouse, Marc, Ding, Min, Ferguson, Deborah A., Meyer, Colin J., Wigley, W. Christian, Ma, Rong
Publicado em 2012

Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2

Por Xing, Yifan, Niu, Ting, Wang, Wenjuan, Li, Jinqing, Li, Siying, Janicki, Joseph S., Ruiz, Stacey, Meyer, Colin J., Wang, Xing Li, Tang, Dongqi, Zhao, Yuxia, Cui, Taixing
Publicado em 2012

Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

Por Li, Wenjuan, Wu, Weiwei, Song, Haibo, Wang, Fang, Li, Huanjie, Chen, Li, Lai, Yimu, Janicki, Joseph S., Ward, Keith W., Meyer, Colin J., Wang, Xing Li, Tang, Dongqi, Cui, Taixing
Publicado no FEBS Lett (2014)

A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas

Por Hong, David S., Kurzrock, Razelle, Supko, Jeffrey G., He, Xiaoying, Naing, Aung, Wheler, Jennifer, Lawrence, Donald, Eder, Joseph Paul, Meyer, Colin J., Ferguson, Deborah A., Mier, James, Konopleva, Marina, Konoplev, Sergej, Andreeff, Michael, Kufe, Donald, Lazarus, Hillard, Shapiro, Geoffrey I., Dezube, Bruce J.
Publicado no Clin Cancer Res (2012)

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

Por de Zeeuw, Dick, Akizawa, Tadao, Audhya, Paul, Bakris, George L., Chin, Melanie, Christ-Schmidt, Heidi, Goldsberry, Angie, Houser, Mark, Krauth, Melissa, Heerspink, Hiddo J. Lambers, McMurray, John J., Meyer, Colin J., Parving, Hans-Henrik, Remuzzi, Giuseppe, Toto, Robert D., Vaziri, Nosratola D., Wanner, Christoph, Wittes, Janet, Wrolstad, Danielle, Chertow, Glenn M.
Publicado no N Engl J Med (2013)