The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

1. Chronic oxidative stress and inflammation are major mediators of chronic kidney disease (CKD) and result in impaired activation of the cytoprotective transcription factor Nrf2. Given the role of oxidative stress and inflammation in CKD pathogenesis, strategies aimed at restoring Nrf2 activity may...

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Bibliographic Details
Main Authors: Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Khazaeli, Mahyar, Yuan, Jun, Meyer, Colin J.
Format: Artigo
Language:Inglês
Published: Informa UK Ltd. 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046874/
https://ncbi.nlm.nih.gov/pubmed/24195589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2013.852705
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