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Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes

Targeting Nrf2 signaling appears to be an attractive approach for the treatment of maladaptive cardiac remodeling and dysfunction; however, pharmacological modulation of the Nrf2 pathway in the cardiovascular system remains to be established. Herein, we report that a novel synthetic triterpenoid der...

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Bibliografiske detaljer
Main Authors: Ichikawa, Tomonaga, Li, Jinqing, Meyer, Colin J., Janicki, Joseph S., Hannink, Mark, Cui, Taixing
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791441/
https://ncbi.nlm.nih.gov/pubmed/20027226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008391
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