Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2

BACKGROUND AND AIMS: Nuclear factor E2-related factor 2 (Nrf2) appears to be an attractive therapeutic target for the treatment of cardiac disease. We investigated whether a synthetic triterpenoid derivative of dihydro-CDDO-trifluoroethylamide (dh404), a novel Nrf2 activator, protects against pathol...

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Detalhes bibliográficos
Main Authors: Xing, Yifan, Niu, Ting, Wang, Wenjuan, Li, Jinqing, Li, Siying, Janicki, Joseph S., Ruiz, Stacey, Meyer, Colin J., Wang, Xing Li, Tang, Dongqi, Zhao, Yuxia, Cui, Taixing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444497/
https://ncbi.nlm.nih.gov/pubmed/23028668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044899
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