Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway regulates phase 2 detoxification genes, including a variety of antioxidative enzymes. We tested neuroprotective effects of the synthetic triterpenoid CDDO-MA, a potent activator of the Nrf2/ARE signaling. CDDO-MA...

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Bibliografiske detaljer
Main Authors: Yang, Lichuan, Calingasan, Noel Y., Thomas, Bobby, Chaturvedi, Rajnish K., Kiaei, Mahmoud, Wille, Elizabeth J., Liby, Karen T., Williams, Charlotte, Royce, Darlene, Risingsong, Renee, Musiek, Eric S., Morrow, Jason D., Sporn, Michael, Beal, M. Flint
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684590/
https://ncbi.nlm.nih.gov/pubmed/19484125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005757
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