Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis

Lung cancer accounts for the highest number of cancer-related deaths in the USA, highlighting the need for better prevention and therapy. Activation of the Nrf2 pathway detoxifies harmful insults and reduces oxidative stress, thus preventing carcinogenesis in various preclinical models. However, con...

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Publicat a:Carcinogenesis
Autors principals: To, Ciric, Ringelberg, Carol S., Royce, Darlene B., Williams, Charlotte R., Risingsong, Renee, Sporn, Michael B., Liby, Karen T.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572919/
https://ncbi.nlm.nih.gov/pubmed/25939751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgv061
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