Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis

Lung cancer accounts for the highest number of cancer-related deaths in the USA, highlighting the need for better prevention and therapy. Activation of the Nrf2 pathway detoxifies harmful insults and reduces oxidative stress, thus preventing carcinogenesis in various preclinical models. However, con...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Carcinogenesis
Prif Awduron: To, Ciric, Ringelberg, Carol S., Royce, Darlene B., Williams, Charlotte R., Risingsong, Renee, Sporn, Michael B., Liby, Karen T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Original Manuscript
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572919/
https://ncbi.nlm.nih.gov/pubmed/25939751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgv061
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