Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

BACKGROUND: Although inhibitors of the renin–angiotensin–aldosterone system can slow the progression of diabetic kidney disease, the residual risk is high. Whether nuclear 1 factor (erythroid-derived 2)–related factor 2 activators further reduce this risk is unknown. METHODS: We randomly assigned 21...

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Pubblicato in:N Engl J Med
Autori principali: de Zeeuw, Dick, Akizawa, Tadao, Audhya, Paul, Bakris, George L., Chin, Melanie, Christ-Schmidt, Heidi, Goldsberry, Angie, Houser, Mark, Krauth, Melissa, Heerspink, Hiddo J. Lambers, McMurray, John J., Meyer, Colin J., Parving, Hans-Henrik, Remuzzi, Giuseppe, Toto, Robert D., Vaziri, Nosratola D., Wanner, Christoph, Wittes, Janet, Wrolstad, Danielle, Chertow, Glenn M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496027/
https://ncbi.nlm.nih.gov/pubmed/24206459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1306033
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