Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

Inflammation and oxidative stress are hallmarks and mediators of the progression of CKD. Bardoxolone methyl, a potent activator of the nuclear factor erythroid 2–related factor 2 (Nrf2)–mediated antioxidant and anti-inflammatory response, increases estimated GFR and decreases BUN, serum phosphorus,...

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Main Authors: Reisman, Scott A., Chertow, Glenn M., Hebbar, Sudarshan, Vaziri, Nosratola D., Ward, Keith W., Meyer, Colin J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2012
Ábhair:
Basic Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458470/
https://ncbi.nlm.nih.gov/pubmed/22859857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050457
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