A Screen to Identify cellular Modulators of Soluble Levels of an Amyotrophic Lateral Sclerosis (ALS)–causing Mutant SOD1

Por SOMALINGA, BALAJEE R., MILLER, GREGORY A., MALIK, HIBA T., WIGLEY, W. CHRISTIAN, THOMAS, PHILIP J.
Publicado em 2011

Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405

Por Probst, Brandon L., McCauley, Lyndsey, Trevino, Isaac, Wigley, W. Christian, Ferguson, Deborah A.
Publicado no PLoS One (2015)

NRF2 as an Emerging Therapeutic Target

Por Copple, Ian M., Dinkova-Kostova, Albena T., Kensler, Thomas W., Liby, Karen T., Wigley, W. Christian
Publicado no Oxid Med Cell Longev (2017)

Hook2 contributes to aggresome formation

Por Szebenyi, Györgyi, Wigley, W Christian, Hall, Branden, Didier, Aaron, Yu, Michelle, Thomas, Philip, Krämer, Helmut
Publicado em 2007

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

Por Probst, Brandon L., Trevino, Isaac, McCauley, Lyndsey, Bumeister, Ron, Dulubova, Irina, Wigley, W. Christian, Ferguson, Deborah A.
Publicado no PLoS One (2015)

Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy

Por Shekh-Ahmad, Tawfeeq, Lieb, Andreas, Kovac, Stjepana, Gola, Lukas, Wigley, W. Christian, Abramov, Andrey Y., Walker, Matthew C.
Publicado no Redox Biol (2019)

The synthetic triterpenoid, RTA405, increases glomerular filtration rate and reduces angiotensin II-induced contraction of glomerular mesangial cells

Por Ding, Yanfeng, Stidham, Rhesa, Bumeister, Ron, Trevino, Isaac, Winters, Ali, Sprouse, Marc, Ding, Min, Ferguson, Deborah A., Meyer, Colin J., Wigley, W. Christian, Ma, Rong
Publicado em 2012

Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function

Por Nagasu, Hajime, Sogawa, Yuji, Kidokoro, Kengo, Itano, Seiji, Yamamoto, Toshiya, Satoh, Minoru, Sasaki, Tamaki, Suzuki, Takafumi, Yamamoto, Masayuki, Wigley, W. Christian, Proksch, Joel W., Meyer, Colin J., Kashihara, Naoki
Publicado no FASEB J (2019)

Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1

Por Wu, Qing Qing, Wang, Yanxia, Senitko, Martin, Meyer, Colin, Wigley, W. Christian, Ferguson, Deborah A., Grossman, Eric, Chen, Jianlin, Zhou, Xin J., Hartono, John, Winterberg, Pamela, Chen, Bo, Agarwal, Anapam, Lu, Christopher Y.
Publicado em 2011

Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD

Por Lewis, James H., Jadoul, Michel, Block, Geoffrey A., Chin, Melanie P., Ferguson, Deborah A., Goldsberry, Angie, Meyer, Colin J., O’Grady, Megan, Pergola, Pablo E., Reisman, Scott A., Wigley, W. Christian, Chertow, Glenn M.
Publicado no Clin Transl Sci (2020)