Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1

Ischemic acute kidney injury (AKI) triggers expression of adaptive (protective) and maladaptive genes. Agents that increase expression of protective genes should provide a therapeutic benefit. We now report that bardoxolone methyl (BARD) ameliorates ischemic murine AKI as assessed by both renal func...

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Bibliografiske detaljer
Main Authors: Wu, Qing Qing, Wang, Yanxia, Senitko, Martin, Meyer, Colin, Wigley, W. Christian, Ferguson, Deborah A., Grossman, Eric, Chen, Jianlin, Zhou, Xin J., Hartono, John, Winterberg, Pamela, Chen, Bo, Agarwal, Anapam, Lu, Christopher Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094059/
https://ncbi.nlm.nih.gov/pubmed/21289052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00353.2010
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