RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation. In the nucleus, Nrf2 increases antioxidant gene expression and reduces pro-inflammatory gene exp...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Probst, Brandon L., Trevino, Isaac, McCauley, Lyndsey, Bumeister, Ron, Dulubova, Irina, Wigley, W. Christian, Ferguson, Deborah A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405374/
https://ncbi.nlm.nih.gov/pubmed/25897966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122942
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