RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation. In the nucleus, Nrf2 increases antioxidant gene expression and reduces pro-inflammatory gene exp...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Probst, Brandon L., Trevino, Isaac, McCauley, Lyndsey, Bumeister, Ron, Dulubova, Irina, Wigley, W. Christian, Ferguson, Deborah A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405374/
https://ncbi.nlm.nih.gov/pubmed/25897966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122942
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