RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation. In the nucleus, Nrf2 increases antioxidant gene expression and reduces pro-inflammatory gene exp...

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Publicado en:PLoS One
Autores principales: Probst, Brandon L., Trevino, Isaac, McCauley, Lyndsey, Bumeister, Ron, Dulubova, Irina, Wigley, W. Christian, Ferguson, Deborah A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405374/
https://ncbi.nlm.nih.gov/pubmed/25897966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122942
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