Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

OBJECTIVE: Oxidative stress is implicated in cardiac insulin resistance, a critical risk factor for cardiac failure, but the direct evidence remains missing. This study explored a causal link between oxidative stress and insulin resistance with a focus on a regulatory role of redox sensitive transcr...

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Detalhes bibliográficos
Main Authors: Tan, Yi, Ichikawa, Tomonaga, Li, Jinqing, Si, Qiusheng, Yang, Huaitao, Chen, Xiangbai, Goldblatt, Curtis S., Meyer, Colin J., Li, Xiaokun, Cai, Lu, Cui, Taixing
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028364/
https://ncbi.nlm.nih.gov/pubmed/21270272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1164
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