Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research

Por Hughes, Christopher S., McConechy, Melissa K., Cochrane, Dawn R., Nazeran, Tayyebeh, Karnezis, Anthony N., Huntsman, David G., Morin, Gregg B.
Publicado no Sci Rep (2016)

Optimizing molecular residual disease detection using liquid biopsy postoperatively in early stage lung cancer

Por McGuire, Anna L, Hughesman, Curtis B, McConechy, Melissa K, Melosky, Barb, Lam, Stephen, Myers, Renelle, Yee, John, Tang, Ernest, Yip, Stephen
Publicado no Lung Cancer Manag (2020)

Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy

Por Bakhsh, Salwa, Kinloch, Mary, Hoang, Lien N, Soslow, Robert, Köbel, Martin, Lee, Cheng-Han, McAlpine, Jessica N, McConechy, Melissa K, Gilks, C Blake
Publicado no Histopathology (2015)

VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock

Por Nakada, Taka-aki, Boyd, John H., Russell, James A., Aguirre-Hernández, Rosalía, Wilkinson, Mark D., Thair, Simone A., Nakada, Emiri, McConechy, Melissa K., Fjell, Christopher D., Walley, Keith R.
Publicado no J Innate Immun (2015)

In‐depth molecular profiling of the biphasic components of uterine carcinosarcomas

Por McConechy, Melissa K, Hoang, Lien N, Chui, Michael Herman, Senz, Janine, Yang, Winnie, Rozenberg, Nirit, Mackenzie, Robertson, McAlpine, Jessica N, Huntsman, David G, Clarke, Blaise A, Gilks, Cyril Blake, Lee, Cheng‐Han
Publicado no J Pathol Clin Res (2015)

Evaluation of endometrial carcinoma prognostic immunohistochemistry markers in the context of molecular classification

Por Karnezis, Anthony N, Leung, Samuel, Magrill, Jamie, McConechy, Melissa K, Yang, Winnie, Chow, Christine, Kobel, Martin, Lee, Cheng-Han, Huntsman, David G, Talhouk, Aline, Kommoss, Friederich, Gilks, C Blake, McAlpine, Jessica N
Publicado no J Pathol Clin Res (2017)

Systematic analysis of somatic mutations impacting gene expression in 12 tumour types

Por Ding, Jiarui, McConechy, Melissa K., Horlings, Hugo M., Ha, Gavin, Chun Chan, Fong, Funnell, Tyler, Mullaly, Sarah C., Reimand, Jüri, Bashashati, Ali, Bader, Gary D., Huntsman, David, Aparicio, Samuel, Condon, Anne, Shah, Sohrab P.
Publicado no Nat Commun (2015)

Interpretation of somatic POLE mutations in endometrial carcinoma

Por León‐Castillo, Alicia, Britton, Heidi, McConechy, Melissa K, McAlpine, Jessica N, Nout, Remi, Kommoss, Stefan, Brucker, Sara Y, Carlson, Joseph W, Epstein, Elisabeth, Rau, Tilman T, Bosse, Tjalling, Church, David N, Gilks, C Blake
Publicado no J Pathol (2020)

Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas

Por Tone, Alicia A, McConechy, Melissa K, Yang, Winnie, Ding, Jiarui, Yip, Stephen, Kong, Esther, Wong, Kwong-Kwok, Gershenson, David M, Mackay, Helen, Shah, Sohrab, Gilks, Blake, Tinker, Anna V, Clarke, Blaise, McAlpine, Jessica N, Huntsman, David
Publicado no BMC Cancer (2014)

Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles

Por McConechy, Melissa K., Ding, Jiarui, Senz, Janine, Yang, Winnie, Melnyk, Nataliya, Tone, Alicia A., Prentice, Leah M., Wiegand, Kimberly, McAlpine, Jessica N., Shah, Sohrab P., Lee, Cheng-Han, Goodfellow, Paul J., Gilks, C. Blake, Huntsman, David G.
Publicado em 2013

Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: earlier prognostic information to guide treatment

Por Talhouk, Aline, Hoang, Lien N., McConechy, Melissa K., Nakonechny, Quentin, Leo, Joyce, Cheng, Angela, Leung, Samuel, Yang, Winnie, Lum, Amy, Köbel, Martin, Lee, Cheng-Han, Soslow, Robert A., Huntsman, David G, Gilks, C. Blake, McAlpine, Jessica N.
Publicado no Gynecol Oncol (2016)

HGG-06. CHARACTERIZING TEMPORAL GENOMIC HETEROGENEITY IN PEDIATRIC HIGH-GRADE GLIOMAS

Por Salloum, Ralph, McConechy, Melissa K., Mikael, Leonie G., Nikhbakht, Hamid, De Jay, Nicolas, Fuller, Christine, Drissi, Rachid, DeWire, Mariko, Boue, Daniel R, Chow, Lionel, Gayden, Tenzin, Karamchandani, Jason, Hummel, Trent, Finlay, Jonathan, Osorio, Diana S, Stevenson, Charles, Kleinman, Claudia, Majewski, Jacek, Jabado, Nada, Fouladi, Maryam
Publicado no Neuro Oncol (2017)

Molecular classification of grade 3 endometrioid endometrial cancers identifies distinct prognostic subgroups

Por Bosse, Tjalling, Nout, Remi A., McAlpine, Jessica N., McConechy, Melissa K., Britton, Heidi, Hussein, Yaser, Gonzalez, Carlene, Ganesan, Raji, Steele, Jane C., Harrison, Beth T., Oliva, Esther, Vidal, August, Matias-Guiu, Xavier, Abu-Rustum, Nadeem R., Levine, Douglas A., Gilks, C. Blake, Soslow, Robert A.
Publicado no Am J Surg Pathol (2018)

Use of mutation profiles to refine the classification of endometrial carcinomas

Por McConechy, Melissa K, Ding, Jiarui, Cheang, Maggie CU, Wiegand, Kimberly, Senz, Janine, Tone, Alicia, Yang, Winnie, Prentice, Leah, Tse, Kane, Zeng, Thomas, McDonald, Helen, Schmidt, Amy P., Mutch, David G., McAlpine, Jessica N, Hirst, Martin, Shah, Sohrab P, Lee, Cheng-Han, Goodfellow, Paul J, Gilks, C. Blake, Huntsman, David G
Publicado em 2012

Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas

Por Salloum, Ralph, McConechy, Melissa K., Mikael, Leonie G., Fuller, Christine, Drissi, Rachid, DeWire, Mariko, Nikbakht, Hamid, De Jay, Nicolas, Yang, Xiaodan, Boue, Daniel, Chow, Lionel M. L., Finlay, Jonathan L., Gayden, Tenzin, Karamchandani, Jason, Hummel, Trent R., Olshefski, Randal, Osorio, Diana S., Stevenson, Charles, Kleinman, Claudia L., Majewski, Jacek, Fouladi, Maryam, Jabado, Nada
Publicado no Acta Neuropathol Commun (2017)

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype

Por McConechy, Melissa K., Färkkilä, Anniina, Horlings, Hugo M., Talhouk, Aline, Unkila-Kallio, Leila, van Meurs, Hannah S., Yang, Winnie, Rozenberg, Nirit, Andersson, Noora, Zaby, Katharina, Bryk, Saara, Bützow, Ralf, Halfwerk, Johannes B. G., Hooijer, Gerrit K. J., van de Vijver, Marc J., Buist, Marrije R., Kenter, Gemma G., Brucker, Sara Y., Krämer, Bernhard, Staebler, Annette, Bleeker, Maaike C. G., Heikinheimo, Markku, Kommoss, Stefan, Blake Gilks, C., Anttonen, Mikko, Huntsman, David G.
Publicado no J Natl Cancer Inst (2016)

Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas

Por Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol CL, Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.
Publicado no Cancer Cell (2019)

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Por Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol C.L., Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.
Publicado no Cancer Cell (2019)

Methylome analysis and whole-exome sequencing reveal that brain tumors associated with encephalocraniocutaneous lipomatosis are midline pilocytic astrocytomas

Por Valera, Elvis Terci, McConechy, Melissa K., Gayden, Tenzin, Rivera, Barbara, Jones, David T. W., Wittmann, Andrea, Han, HyeRim, Bareke, Eric, Nikbakht, Hamid, Mikael, Leonie, Queiroz, Rosane Gomes, Suazo, Veridiana Kiill, Phi, Ji Hoon, Kim, Seung-Ki, Park, Sung-Hye, Fukaya, Raita, Yum, Mi-Sun, Ko, Tae-Sung, de Oliveira, Ricardo Santos, Machado, Helio Rubens, Brassesco, María Sol, do Santos, Antonio Carlos, Simão, Gustavo Novelino, Ramalho, Leandra Náira Zambelli, Neder, Luciano, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Majewski, Jacek, Jabado, Nada
Publicado no Acta Neuropathol (2018)

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Por Harutyunyan, Ashot S., Krug, Brian, Chen, Haifen, Papillon-Cavanagh, Simon, Zeinieh, Michele, De Jay, Nicolas, Deshmukh, Shriya, Chen, Carol C. L., Belle, Jad, Mikael, Leonie G., Marchione, Dylan M., Li, Rui, Nikbakht, Hamid, Hu, Bo, Cagnone, Gael, Cheung, Warren A., Mohammadnia, Abdulshakour, Bechet, Denise, Faury, Damien, McConechy, Melissa K, Pathania, Manav, Jain, Siddhant U., Ellezam, Benjamin, Weil, Alexander G., Montpetit, Alexandre, Salomoni, Paolo, Pastinen, Tomi, Lu, Chao, Lewis, Peter W., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Majewski, Jacek
Publicado no Nat Commun (2019)