Systematic analysis of somatic mutations impacting gene expression in 12 tumour types

We present a novel hierarchical Bayes statistical model, xseq, to systematically quantify the impact of somatic mutations on expression profiles. We establish the theoretical framework and robust inference characteristics of the method using computational benchmarking. We then use xseq to analyse th...

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Udgivet i:Nat Commun
Main Authors: Ding, Jiarui, McConechy, Melissa K., Horlings, Hugo M., Ha, Gavin, Chun Chan, Fong, Funnell, Tyler, Mullaly, Sarah C., Reimand, Jüri, Bashashati, Ali, Bader, Gary D., Huntsman, David, Aparicio, Samuel, Condon, Anne, Shah, Sohrab P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600750/
https://ncbi.nlm.nih.gov/pubmed/26436532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9554
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