Can pharmacological receptor tyrosine kinase inhibitors sensitize poor outcome breast tumors to immune-based therapies?

por Ursini-Siegel, Josie
Publicado em 2013

It takes two to tango in the microenvironment!

por Ursini-Siegel, Josie, Park, Morag
Publicado em 2013

Clinical Potential of Kinase Inhibitors in Combination with Immune Checkpoint Inhibitors for the Treatment of Solid Tumors

por Ahn, Ryuhjin, Ursini-Siegel, Josie
Publicado no Int J Mol Sci (2021)

A complex containing LPP and α-Actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells

por Ngan, Elaine, Northey, Jason J., Brown, Claire M., Ursini-Siegel, Josie, Siegel, Peter M.
Publicado em 2013

Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

por Déry, Marc-André, Jodoin, Julie, Ursini-Siegel, Josie, Aleynikova, Olga, Ferrario, Cristiano, Hassan, Saima, Basik, Mark, LeBlanc, Andréa C
Publicado em 2013

Peripheral blood cells inform on the presence of breast cancer: A population-based case–control study

por Dumeaux, Vanessa, Ursini-Siegel, Josie, Flatberg, Arnar, Fjosne, Hans E, Frantzen, Jan-Ole, Holmen, Marit Muri, Rodegerdts, Enno, Schlichting, Ellen, Lund, Eiliv
Publicado no Int J Cancer (2015)

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

por Ursini-Siegel, Josie, Hardy, W Rod, Zuo, Dongmei, Lam, Sonya H L, Sanguin-Gendreau, Virginie, Cardiff, Robert D, Pawson, Tony, Muller, William J
Publicado em 2008

Tungsten Targets the Tumor Microenvironment to Enhance Breast Cancer Metastasis

por Bolt, Alicia M., Sabourin, Valérie, Molina, Manuel Flores, Police, Alice M., Negro Silva, Luis Fernando, Plourde, Dany, Lemaire, Maryse, Ursini-Siegel, Josie, Mann, Koren K.
Publicado no Toxicol Sci (2015)

Stat3 establishes an immunosuppressive microenvironment during the early stages of breast carcinogenesis to promote tumor growth and metastasis

por Jones, Laura M., Broz, Miranda L., Ranger, Jill J., Ozcelik, John, Ahn, Ryuhjin, Zuo, Dongmei, Ursini-Siegel, Josie, Hallett, Michael T., Krummel, Matthew, Muller, William J.
Publicado no Cancer Res (2015)

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors

por Cañedo, Eduardo Cepeda, Totten, Stephanie, Ahn, Ryuhjin, Savage, Paul, MacNeil, Deanna, Hudson, Jesse, Autexier, Chantal, Deblois, Genevieve, Park, Morag, Witcher, Michael, Ursini-Siegel, Josie
Publicado no JCI Insight (2021)

The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation

por Kiepas, Alex, Voorand, Elena, Senecal, Julien, Ahn, Ryuhjin, Annis, Matthew G., Jacquet, Kévin, Tali, George, Bisson, Nicolas, Ursini-Siegel, Josie, Siegel, Peter M., Brown, Claire M.
Publicado no J Biol Chem (2020)

Elevated Expression of DecR1 Impairs ErbB2/Neu-Induced Mammary Tumor Development

por Ursini-Siegel, Josie, Rajput, Ashish B., Lu, Huiling, Sanguin-Gendreau, Virginie, Zuo, Dongmei, Papavasiliou, Vasilios, Lavoie, Cynthia, Turpin, Jason, Cianflone, Katherine, Huntsman, David G., Muller, William J.
Publicado em 2007

p66ShcA Promotes Breast Cancer Plasticity by Inducing an Epithelial-to-Mesenchymal Transition

por Hudson, Jesse, Ha, Jacqueline R., Sabourin, Valerie, Ahn, Ryuhjin, La Selva, Rachel, Livingstone, Julie, Podmore, Lauren, Knight, Jennifer, Forrest, Laura, Beauchemin, Nicole, Hallett, Michael, Park, Morag, Ursini-Siegel, Josie
Publicado em 2014

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity

por Dannenfelser, Ruth, Nome, Marianne, Tahiri, Andliena, Ursini-Siegel, Josie, Vollan, Hans Kristian Moen, Haakensen, Vilde D., Helland, Åslaug, Naume, Bjørn, Caldas, Carlos, Børresen-Dale, Anne-Lise, Kristensen, Vessela N., Troyanskaya, Olga G.
Publicado no Oncotarget (2017)

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

por Darini, Cedric, Ghaddar, Nour, Chabot, Catherine, Assaker, Gloria, Sabri, Siham, Wang, Shuo, Krishnamoorthy, Jothilatha, Buchanan, Marguerite, Aguilar-Mahecha, Adriana, Abdulkarim, Bassam, Deschenes, Jean, Torres, Jose, Ursini-Siegel, Josie, Basik, Mark, Koromilas, Antonis E.
Publicado no Nat Commun (2019)

Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling

por Kristensen, Vessela N., Vaske, Charles J., Ursini-Siegel, Josie, Van Loo, Peter, Nordgard, Silje H., Sachidanandam, Ravi, Sørlie, Therese, Wärnberg, Fredrik, Haakensen, Vilde D., Helland, Åslaug, Naume, Bjørn, Perou, Charles M., Haussler, David, Troyanskaya, Olga G., Børresen-Dale, Anne-Lise
Publicado em 2012

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

por Ahn, Ryuhjin, Sabourin, Valérie, Bolt, Alicia M., Hébert, Steven, Totten, Stephanie, De Jay, Nicolas, Festa, Maria Carolina, Young, Yoon Kow, Im, Young Kyuen, Pawson, Tony, Koromilas, Antonis E., Muller, William J., Mann, Koren K., Kleinman, Claudia L., Ursini-Siegel, Josie
Publicado no Nat Commun (2017)

Receptor Tyrosine Kinase Signaling Favors a Protumorigenic State in Breast Cancer Cells by Inhibiting the Adaptive Immune Response

por Ursini-Siegel, Josie, Cory, Sean, Zuo, Dongmei, Hardy, William R., Rexhepaj, Elton, Lam, Sonya, Schade, Babette, Jirstrom, Karin, Bjur, Eva, Piccirillo, Ciriaco A., DeNardo, David, Coussens, Lisa M., Brennan, Donal J., Gallagher, William M., Park, Morag, Pawson, Tony, Hallett, Michael, Muller, William J.
Publicado em 2010

p66ShcA functions as a contextual promoter of breast cancer metastasis

por Lewis, Kyle, Kiepas, Alex, Hudson, Jesse, Senecal, Julien, Ha, Jacqueline R., Voorand, Elena, Annis, Matthew G., Sabourin, Valerie, Ahn, Ryuhjin, La Selva, Rachel, Tabariès, Sébastien, Hsu, Brian E., Siegel, Matthew J., Dankner, Matthew, Canedo, Eduardo Cepeda, Lajoie, Mathieu, Watson, Ian R., Brown, Claire M., Siegel, Peter M., Ursini-Siegel, Josie
Publicado no Breast Cancer Res (2020)

Translational and HIF-1α-dependent metabolic reprogramming underpin metabolic plasticity and determine responses to kinase inhibitors and biguanides.

por Hulea, Laura, Gravel, Simon-Pierre, Morita, Masahiro, Cargnello, Marie, Uchenunu, Oro, Im, Young Kyuen, Lehuédé, Camille, Ma, Eric H., Leibovitch, Matthew, McLaughlan, Shannon, Blouin, Marie-José, Parisotto, Maxime, Papavasiliou, Vasilios, Lavoie, Cynthia, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaëlle, Avizonis, Daina, Ferbeyre, Gerardo, Siegel, Peter, Jones, Russell G., Muller, William, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan
Publicado no Cell Metab (2018)