An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

Trastuzumab is integral to HER2+ cancer treatment, but its therapeutic index is narrowed by the development of resistance. Phosphorylation of the translation initiation factor eIF2α (eIF2α-P) is the nodal point of the integrated stress response, which promotes survival or death in a context-dependen...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Darini, Cedric, Ghaddar, Nour, Chabot, Catherine, Assaker, Gloria, Sabri, Siham, Wang, Shuo, Krishnamoorthy, Jothilatha, Buchanan, Marguerite, Aguilar-Mahecha, Adriana, Abdulkarim, Bassam, Deschenes, Jean, Torres, Jose, Ursini-Siegel, Josie, Basik, Mark, Koromilas, Antonis E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513990/
https://ncbi.nlm.nih.gov/pubmed/31086176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10138-8
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