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Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2α Phosphorylation Pathway
Inhibition of protein synthesis by phosphorylation of the a subunit of eukaryotic translation initiation factor 2 (eIF2) at Ser(51) occurs as a result of the activation of a family of kinases in response to various forms of stress. Although some consequences of eIF2α phosphorylation are cytoprotecti...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3684442/ https://ncbi.nlm.nih.gov/pubmed/20029030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000389 |
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