In Vivo Replication of an ICP34.5 Second-Site Suppressor Mutant following Corneal Infection Correlates with In Vitro Regulation of eIF2α Phosphorylation

In animal models of herpes simplex virus type 1 (HSV-1) infection, ICP34.5-null viruses are avirulent and also fail to grow in a variety of cultured cells due to their inability to prevent RNA-dependent protein kinase (PKR)-mediated inhibition of protein synthesis. We show here that the inability of...

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Detalhes bibliográficos
Main Authors: Ward, Stephen L., Scheuner, Donalyn, Poppers, Jeremy, Kaufman, Randal J., Mohr, Ian, Leib, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152123/
https://ncbi.nlm.nih.gov/pubmed/12663769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4626-4634.2003
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