Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications

The endoplasmic reticulum (ER)-resident protein kinase PERK is a major component of the unfolded protein response (UPR), which promotes the adaptation of cells to various forms of stress. PERK phosphorylates the α subunit of the translation initiation factor eIF2 at serine 51, a modification that pl...

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Main Authors: Krishnamoorthy, Jothilatha, Rajesh, Kamindla, Mirzajani, Farzaneh, Kesoglidou, Polixenia, Papadakis, Andreas I, Koromilas, Antonis E
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2014
Ábhair:
Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979916/
https://ncbi.nlm.nih.gov/pubmed/24401334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27726
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