eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies

Eukaryotic cells respond to various forms of stress by blocking mRNA translation initiation via the phosphorylation of the alpha (α) subunit of eIF2 at serine 51 (S51) (eIFαP). An important role of eIF2αP is the regulation of redox homeostasis and adaptation of cells to oxidative stress. Herein, we...

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Main Authors: Rajesh, Kamindla, Papadakis, Andreas I., Kazimierczak, Urszula, Peidis, Philippos, Wang, Shuo, Ferbeyre, Gerardo, Kaufman, Randal J., Koromilas, Antonis E.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2013
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883705/
https://ncbi.nlm.nih.gov/pubmed/24334569
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