HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2

Histone deacetylase inhibitors (HDACi) comprise a family of chemotherapeutic agents used in the clinic to treat cutaneous T-cell lymphoma and tested for the therapy of other malignancies. Previous reports have shown that eIF2α phosphorylation is induced upon treatment with HDACi. However the kinase...

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Autores principales: Peidis, Philippos, Papadakis, Andreas I., Rajesh, Kamindla, Koromilas, Antonis E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2010
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993797/
https://ncbi.nlm.nih.gov/pubmed/21076179
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