Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

Oxidative stress determines cell fate through several mechanisms, among which regulation of mRNA translation by the phosphorylation of the alpha (α) subunit of the translation initiation factor eIF2α at serine 51 (eIF2αP) plays a prominent role. Increased eIF2αP can contribute to tumor progression a...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Krishnamoorthy, Jothilatha, Tenkerian, Clara, Gupta, Jyotsana, Ghaddar, Nour, Wang, Shuo, Darini, Cedric, Staschke, Kirk A., Ghosh, Abhishek, Gandin, Valentina, Topisirovic, Ivan, Kristof, Arnold S., Hatzoglou, Maria, Simos, George, Koromilas, Antonis E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833713/
https://ncbi.nlm.nih.gov/pubmed/29449538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0326-2
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