Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress

Phosphorylation of the α subunit of the translation initiation factor eIF2 at serine 51 (eIF2αP) is a master regulator of cell adaptation to various forms of stress with implications in antitumor treatments with chemotherapeutic drugs. Herein, we demonstrate that genetic loss of the eIF2α kinases PE...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Rajesh, K, Krishnamoorthy, J, Kazimierczak, U, Tenkerian, C, Papadakis, A I, Wang, S, Huang, S, Koromilas, A E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669752/
https://ncbi.nlm.nih.gov/pubmed/25590801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.554
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