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ShcA signalling is essential for tumour progression in mouse models of human breast cancer
To explore the in vivo significance of ShcA during mammary tumorigenesis, we used mice expressing several phosphotyrosine-deficient ShcA alleles under the control of their endogenous promoter. We show that all three ShcA tyrosine phosphorylation sites are involved in the early stages of mammary tumo...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2274931/ https://ncbi.nlm.nih.gov/pubmed/18273058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.22 |
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