ShcA signalling is essential for tumour progression in mouse models of human breast cancer

To explore the in vivo significance of ShcA during mammary tumorigenesis, we used mice expressing several phosphotyrosine-deficient ShcA alleles under the control of their endogenous promoter. We show that all three ShcA tyrosine phosphorylation sites are involved in the early stages of mammary tumo...

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Bibliographic Details
Main Authors: Ursini-Siegel, Josie, Hardy, W Rod, Zuo, Dongmei, Lam, Sonya H L, Sanguin-Gendreau, Virginie, Cardiff, Robert D, Pawson, Tony, Muller, William J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2274931/
https://ncbi.nlm.nih.gov/pubmed/18273058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.22
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