The ShcA Phosphotyrosine Docking Protein Uses Distinct Mechanisms to Regulate Myocyte and Global Heart Function

RATIONALE: Although tyrosine kinases (TKs) are important for cardiac function, their relevant downstream targets in the adult heart are unknown. The ShcA docking protein binds specific phosphotyrosine (pTyr) sites on activated TKs through its N-terminal pTyr-binding (PTB) and C-terminal SH2 domains...

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Main Authors: Vanderlaan, Rachel D., Hardy, W. Rod, Kabir, M. Golam, Pasculescu, Adrian, Jones, Nina, deTombe, Pieter P., Backx, Peter H., Pawson, Tony
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109628/
https://ncbi.nlm.nih.gov/pubmed/21148430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.233924
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