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The ShcA Phosphotyrosine Docking Protein Uses Distinct Mechanisms to Regulate Myocyte and Global Heart Function

RATIONALE: Although tyrosine kinases (TKs) are important for cardiac function, their relevant downstream targets in the adult heart are unknown. The ShcA docking protein binds specific phosphotyrosine (pTyr) sites on activated TKs through its N-terminal pTyr-binding (PTB) and C-terminal SH2 domains...

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מידע ביבליוגרפי
Main Authors: Vanderlaan, Rachel D., Hardy, W. Rod, Kabir, M. Golam, Pasculescu, Adrian, Jones, Nina, deTombe, Pieter P., Backx, Peter H., Pawson, Tony
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109628/
https://ncbi.nlm.nih.gov/pubmed/21148430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.233924
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