The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1

Adaptor proteins respond to stimuli and recruit downstream complexes using interactions conferred by associated protein domains and linear motifs. The ShcA adaptor contains two phosphotyrosine recognition modules responsible for binding activated receptors, resulting in the subsequent recruitment of...

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Bibliographic Details
Main Authors: Smith, Matthew J, Hardy, W Rod, Li, Guang-Yao, Goudreault, Marilyn, Hersch, Steven, Metalnikov, Pavel, Starostine, Andrei, Pawson, Tony, Ikura, Mitsuhiko
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837165/
https://ncbi.nlm.nih.gov/pubmed/20075861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.399
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