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The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1

Adaptor proteins respond to stimuli and recruit downstream complexes using interactions conferred by associated protein domains and linear motifs. The ShcA adaptor contains two phosphotyrosine recognition modules responsible for binding activated receptors, resulting in the subsequent recruitment of...

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Bibliografski detalji
Glavni autori: Smith, Matthew J, Hardy, W Rod, Li, Guang-Yao, Goudreault, Marilyn, Hersch, Steven, Metalnikov, Pavel, Starostine, Andrei, Pawson, Tony, Ikura, Mitsuhiko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837165/
https://ncbi.nlm.nih.gov/pubmed/20075861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.399
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