Receptor Tyrosine Kinase Signaling Favors a Protumorigenic State in Breast Cancer Cells by Inhibiting the Adaptive Immune Response

Using transgenic mouse models of breast cancer that ablate Src homology and collagen A (ShcA) expression or oncogene-coupled ShcA signaling, we previously showed that this adaptor is critical for mammary tumor onset and progression. We now provide the first evidence that ShcA regulates mammary tumor...

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Detalhes bibliográficos
Main Authors: Ursini-Siegel, Josie, Cory, Sean, Zuo, Dongmei, Hardy, William R., Rexhepaj, Elton, Lam, Sonya, Schade, Babette, Jirstrom, Karin, Bjur, Eva, Piccirillo, Ciriaco A., DeNardo, David, Coussens, Lisa M., Brennan, Donal J., Gallagher, William M., Park, Morag, Pawson, Tony, Hallett, Michael, Muller, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660232/
https://ncbi.nlm.nih.gov/pubmed/20924104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2229
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