Elevated Expression of DecR1 Impairs ErbB2/Neu-Induced Mammary Tumor Development

Tumor cells utilize glucose as a primary energy source and require ongoing lipid biosynthesis for growth. Expression of DecR1, an auxiliary enzyme in the fatty acid β-oxidation pathway, is significantly diminished in numerous spontaneous mammary tumor models and in primary human breast cancer. Moreo...

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Main Authors: Ursini-Siegel, Josie, Rajput, Ashish B., Lu, Huiling, Sanguin-Gendreau, Virginie, Zuo, Dongmei, Papavasiliou, Vasilios, Lavoie, Cynthia, Turpin, Jason, Cianflone, Katherine, Huntsman, David G., Muller, William J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099621/
https://ncbi.nlm.nih.gov/pubmed/17636013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00686-07
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