p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors

Triple-negative breast cancers (TNBCs) lack effective targeted therapies, and cytotoxic chemotherapies remain the standard of care for this subtype. Owing to their increased genomic instability, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are being tested against TNBCs. In particular, cli...

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Pubblicato in:JCI Insight
Autori principali: Cañedo, Eduardo Cepeda, Totten, Stephanie, Ahn, Ryuhjin, Savage, Paul, MacNeil, Deanna, Hudson, Jesse, Autexier, Chantal, Deblois, Genevieve, Park, Morag, Witcher, Michael, Ursini-Siegel, Josie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934920/
https://ncbi.nlm.nih.gov/pubmed/33470989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138382
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