p66ShcA functions as a contextual promoter of breast cancer metastasis

BACKGROUND: The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the cytoplasm to the mitochondria where it stimulate...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Lewis, Kyle, Kiepas, Alex, Hudson, Jesse, Senecal, Julien, Ha, Jacqueline R., Voorand, Elena, Annis, Matthew G., Sabourin, Valerie, Ahn, Ryuhjin, La Selva, Rachel, Tabariès, Sébastien, Hsu, Brian E., Siegel, Matthew J., Dankner, Matthew, Canedo, Eduardo Cepeda, Lajoie, Mathieu, Watson, Ian R., Brown, Claire M., Siegel, Peter M., Ursini-Siegel, Josie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964019/
https://ncbi.nlm.nih.gov/pubmed/31941526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-1245-6
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