p66ShcA functions as a contextual promoter of breast cancer metastasis

BACKGROUND: The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the cytoplasm to the mitochondria where it stimulate...

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Bibliografiske detaljer
Udgivet i:Breast Cancer Res
Main Authors: Lewis, Kyle, Kiepas, Alex, Hudson, Jesse, Senecal, Julien, Ha, Jacqueline R., Voorand, Elena, Annis, Matthew G., Sabourin, Valerie, Ahn, Ryuhjin, La Selva, Rachel, Tabariès, Sébastien, Hsu, Brian E., Siegel, Matthew J., Dankner, Matthew, Canedo, Eduardo Cepeda, Lajoie, Mathieu, Watson, Ian R., Brown, Claire M., Siegel, Peter M., Ursini-Siegel, Josie
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964019/
https://ncbi.nlm.nih.gov/pubmed/31941526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-1245-6
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