Immune Response Mechanisms against AAV Vectors in Animal Models

Por Martino, Ashley T., Markusic, David M.
Publicado no Mol Ther Methods Clin Dev (2019)

Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia

Por Markusic, David M., Herzog, Roland W
Publicado em 2012

Separating Lentiviral Vector Injection and Induction of Gene Expression in Time, Does Not Prevent an Immune Response to rtTA in Rats

Por Markusic, David M., de Waart, Dirk R., Seppen, Jurgen
Publicado em 2010

Liver Induced Transgene Tolerance with AAV Vectors

Por Keeler, Geoffrey D., Markusic, David M., Hoffman, Brad E.
Publicado no Cell Immunol (2017)

Update on clinical gene therapy for hemophilia

Por Perrin, George Q., Herzog, Roland W., Markusic, David M.
Publicado no Blood (2019)

Development of gene transfer for induction of antigen-specific tolerance

Por Sack, Brandon K, Herzog, Roland W, Terhorst, Cox, Markusic, David M
Publicado no Mol Ther Methods Clin Dev (2014)

Immunology of Gene and Cell Therapy

Por Markusic, David M., Martino, Ashley T., Porada, Christopher D., VandenDriessche, Thierry
Publicado no Mol Ther (2020)

AAV Vector Biology in Primates: Finding the Missing Link?

Por Herzog, Roland W, Davidoff, Andrew M, Markusic, David M, Nathwani, Amit C
Publicado em 2011

An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8(+) T Cells

Por Palaschak, Brett, Marsic, Damien, Herzog, Roland W., Zolotukhin, Sergei, Markusic, David M.
Publicado no Mol Ther Methods Clin Dev (2017)

B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

Por Biswas, Moanaro, Palaschak, Brett, Kumar, Sandeep R. P., Rana, Jyoti, Markusic, David M.
Publicado no Front Immunol (2020)

Clinical development of gene therapy: results and lessons from recent successes

Por Kumar, Sandeep RP, Markusic, David M, Biswas, Moanaro, High, Katherine A, Herzog, Roland W
Publicado no Mol Ther Methods Clin Dev (2016)

Tolerance Induction to Factor VIII by Transient Co-administration with Rapamycin

Por Moghimi, Babak, Sack, Brandon K., Nayak, Sushrusha, Markusic, David M., Mah, Cathryn S., Herzog, Roland W.
Publicado em 2011

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain

Por Markusic, David M, van Til, Niek P, Hiralall, Johan K, Elferink, Ronald PJ Oude, Seppen, Jurgen
Publicado em 2009

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

Por Zolotukhin, Irene, Markusic, David M, Palaschak, Brett, Hoffman, Brad E, Srikanthan, Meera A, Herzog, Roland W
Publicado no Mol Ther Methods Clin Dev (2016)

Combination Therapy for Inhibitor Reversal in Haemophilia A Using Monoclonal Anti-CD20 and Rapamycin

Por Biswas, Moanaro, Rogers, Geoffrey L., Sherman, Alexandra, Byrne, Barry J., Markusic, David M., Jiang, Haiyan, Herzog, Roland W.
Publicado no Thromb Haemost (2016)

Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis

Por Keeler, Geoffrey D., Kumar, Sandeep, Palaschak, Brett, Silverberg, Emily L., Markusic, David M., Jones, Noah T., Hoffman, Brad E.
Publicado no Mol Ther (2018)

Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy

Por Sack, Brandon K., Merchant, Sherin, Markusic, David M., Nathwani, Amit C., Davidoff, Andrew M., Byrne, Barry J., Herzog, Roland W.
Publicado em 2012

Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Ve...

Por Kwon, Hyung-Joo, Qing, Keyun, Ponnazhagan, Selvarangan, Wang, Xu-Shan, Markusic, David M., Gupte, Siddhant, Boye, Shannon E., Srivastava, Arun
Publicado no Hum Gene Ther (2020)

Vector Design Tour de Force: Integrating Combinatorial and Rational Approaches to Derive Novel Adeno-associated Virus Variants

Por Marsic, Damien, Govindasamy, Lakshmanan, Currlin, Seth, Markusic, David M, Tseng, Yu-Shan, Herzog, Roland W, Agbandje-McKenna, Mavis, Zolotukhin, Sergei
Publicado no Mol Ther (2014)

Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B

Por Brown, Harrison C., Doering, Christopher B., Herzog, Roland W., Ling, Chen, Markusic, David M., Spencer, H. Trent, Srivastava, Alok, Srivastava, Arun
Publicado no Hum Gene Ther (2020)