Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia

Por Markusic, David M., Herzog, Roland W
Publicado em 2012

Separating Lentiviral Vector Injection and Induction of Gene Expression in Time, Does Not Prevent an Immune Response to rtTA in Rats

Por Markusic, David M., de Waart, Dirk R., Seppen, Jurgen
Publicado em 2010

Development of gene transfer for induction of antigen-specific tolerance

Por Sack, Brandon K, Herzog, Roland W, Terhorst, Cox, Markusic, David M
Publicado no Mol Ther Methods Clin Dev (2014)

AAV Vector Biology in Primates: Finding the Missing Link?

Por Herzog, Roland W, Davidoff, Andrew M, Markusic, David M, Nathwani, Amit C
Publicado em 2011

Clinical development of gene therapy: results and lessons from recent successes

Por Kumar, Sandeep RP, Markusic, David M, Biswas, Moanaro, High, Katherine A, Herzog, Roland W
Publicado no Mol Ther Methods Clin Dev (2016)

Tolerance Induction to Factor VIII by Transient Co-administration with Rapamycin

Por Moghimi, Babak, Sack, Brandon K., Nayak, Sushrusha, Markusic, David M., Mah, Cathryn S., Herzog, Roland W.
Publicado em 2011

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain

Por Markusic, David M, van Til, Niek P, Hiralall, Johan K, Elferink, Ronald PJ Oude, Seppen, Jurgen
Publicado em 2009

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

Por Zolotukhin, Irene, Markusic, David M, Palaschak, Brett, Hoffman, Brad E, Srikanthan, Meera A, Herzog, Roland W
Publicado no Mol Ther Methods Clin Dev (2016)

Combination Therapy for Inhibitor Reversal in Haemophilia A Using Monoclonal Anti-CD20 and Rapamycin

Por Biswas, Moanaro, Rogers, Geoffrey L., Sherman, Alexandra, Byrne, Barry J., Markusic, David M., Jiang, Haiyan, Herzog, Roland W.
Publicado no Thromb Haemost (2016)

Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy

Por Sack, Brandon K., Merchant, Sherin, Markusic, David M., Nathwani, Amit C., Davidoff, Andrew M., Byrne, Barry J., Herzog, Roland W.
Publicado em 2012

Vector Design Tour de Force: Integrating Combinatorial and Rational Approaches to Derive Novel Adeno-associated Virus Variants

Por Marsic, Damien, Govindasamy, Lakshmanan, Currlin, Seth, Markusic, David M, Tseng, Yu-Shan, Herzog, Roland W, Agbandje-McKenna, Mavis, Zolotukhin, Sergei
Publicado no Mol Ther (2014)

Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

Por Martino, Ashley T., Nayak, Sushrusha, Hoffman, Brad E., Cooper, Mario, Liao, Gongxian, Markusic, David M., Byrne, Barry J., Terhorst, Cox, Herzog, Roland W.
Publicado em 2009

Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer

Por Rogers, Geoffrey L., Suzuki, Masataka, Zolotukhin, Irene, Markusic, David M., Morel, Laurence M., Lee, Brendan, Ertl, Hildegund C.J., Herzog, Roland W.
Publicado no J Innate Immun (2015)

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

Por Markusic, David M, Hoffman, Brad E, Perrin, George Q, Nayak, Sushrusha, Wang, Xiaomei, LoDuca, Paul A, High, Katherine A, Herzog, Roland W
Publicado em 2013

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell–dependent induction of CD4(+)CD25(+)FoxP3(+) Treg

Por Biswas, Moanaro, Sarkar, Debalina, Kumar, Sandeep R. P., Nayak, Sushrusha, Rogers, Geoffrey L., Markusic, David M., Liao, Gongxian, Terhorst, Cox, Herzog, Roland W.
Publicado no Blood (2015)

Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity

Por van Til, Niek P, Heutinck, Kirstin M, van der Rijt, Roos, Paulusma, Coen C, van Wijland, Michel, Markusic, David M, Elferink, Ronald PJ Oude, Seppen, Jurgen
Publicado em 2008

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver

Por Martino, Ashley T., Suzuki, Masataka, Markusic, David M., Zolotukhin, Irene, Ryals, Renee C., Moghimi, Babak, Ertl, Hildegund C. J., Muruve, Daniel A., Lee, Brendan, Herzog, Roland W.
Publicado em 2011

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

Por Sarkar, Debalina, Biswas, Moanaro, Liao, Gongxian, Seay, Howard R, Perrin, George Q, Markusic, David M, Hoffman, Brad E, Brusko, Todd M, Terhorst, Cox, Herzog, Roland W
Publicado em 2014

High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines

Por Markusic, David M, Herzog, Roland W, Aslanidi, George V, Hoffman, Brad E, Li, Baozheng, Li, Mengxin, Jayandharan, Giridhara R., Ling, Chen, Zolotukhin, Irene, Ma, Wenqin, Zolotukhin, Sergei, Srivastava, Arun, Zhong, Li
Publicado em 2010

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8(+) T cells

Por Martino, Ashley T., Basner-Tschakarjan, Etiena, Markusic, David M., Finn, Jonathan D., Hinderer, Christian, Zhou, Shangzhen, Ostrov, David A., Srivastava, Arun, Ertl, Hildegund C. J., Terhorst, Cox, High, Katherine A., Mingozzi, Federico, Herzog, Roland W.
Publicado em 2013