B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

Hemophilia A is an inherited coagulation disorder resulting in the loss of functional clotting factor VIII (FVIII). Presently, the most effective treatment is prophylactic protein replacement therapy. However, this requires frequent life-long intravenous infusions of plasma derived or recombinant cl...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Biswas, Moanaro, Palaschak, Brett, Kumar, Sandeep R. P., Rana, Jyoti, Markusic, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327091/
https://ncbi.nlm.nih.gov/pubmed/32670285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01293
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