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Effect of CpG Depletion of Vector Genome on CD8(+) T Cell Responses in AAV Gene Therapy
Adeno associated viral (AAV) vectors have emerged as a preferred platform for in vivo gene replacement therapy and represent one of the most promising strategies to treat monogenetic disorders such as hemophilia. However, immune responses to gene transfer have hampered human gene therapy in clinical...
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| Pubblicato in: | Front Immunol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8200677/ https://ncbi.nlm.nih.gov/pubmed/34135899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.672449 |
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