Effect of CpG Depletion of Vector Genome on CD8(+) T Cell Responses in AAV Gene Therapy

Adeno associated viral (AAV) vectors have emerged as a preferred platform for in vivo gene replacement therapy and represent one of the most promising strategies to treat monogenetic disorders such as hemophilia. However, immune responses to gene transfer have hampered human gene therapy in clinical...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Bertolini, Thais B., Shirley, Jamie L., Zolotukhin, Irene, Li, Xin, Kaisho, Tsuneyasu, Xiao, Weidong, Kumar, Sandeep R. P., Herzog, Roland W.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8200677/
https://ncbi.nlm.nih.gov/pubmed/34135899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.672449
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares