Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8(+) T cells

Adeno-associated virus (AAV) is a replication-deficient parvovirus that is extensively used as a gene therapy vector. CD8(+) T-cell responses against the AAV capsid protein can, however, affect therapeutic efficacy. Little is known about the in vivo mechanism that leads to the crosspriming of CD8(+)...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Rogers, Geoffrey L., Shirley, Jamie L., Zolotukhin, Irene, Kumar, Sandeep R. P., Sherman, Alexandra, Perrin, George Q., Hoffman, Brad E., Srivastava, Arun, Basner-Tschakarjan, Etiena, Wallet, Mark A., Terhorst, Cox, Biswas, Moanaro, Herzog, Roland W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472899/
https://ncbi.nlm.nih.gov/pubmed/28468798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-751040
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