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Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8(+) T cells
Recent clinical trials have shown that evasion of CD8(+) T-cell responses against viral capsid is critical for successful liver-directed gene therapy with adeno-associated viral (AAV) vectors for hemophilia. Preclinical models to test whether use of alternate serotypes or capsid variants could avoid...
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| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3606062/ https://ncbi.nlm.nih.gov/pubmed/23325831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-460733 |
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