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Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
Adeno-associated virus (AAV) vectors delivered through the systemic circulation successfully transduce various target tissues in animal models. However, similar attempts in humans have been hampered by the high prevalence of neutralizing antibodies to AAV, which completely block vector transduction....
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| 主要な著者: | , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4095828/ https://ncbi.nlm.nih.gov/pubmed/23863832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005795 |
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