Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

Adeno-associated virus (AAV) vectors delivered through the systemic circulation successfully transduce various target tissues in animal models. However, similar attempts in humans have been hampered by the high prevalence of neutralizing antibodies to AAV, which completely block vector transduction....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mingozzi, Federico, Anguela, Xavier M., Pavani, Giulia, Chen, Yifeng, Davidson, Robert J., Hui, Daniel J., Yazicioglu, Mustafa, Elkouby, Liron, Hinderer, Christian J., Faella, Armida, Howard, Carolann, Tai, Alex, Podsakoff, Gregory M., Zhou, Shangzhen, Basner-Tschakarjan, Etiena, Wright, John Fraser, High, Katherine A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095828/
https://ncbi.nlm.nih.gov/pubmed/23863832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005795
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