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AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes

Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe. Administration to humans, however, revealed that adaptive immu...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Ther Methods Clin Dev
Main Authors: Hui, Daniel J, Edmonson, Shyrie C, Podsakoff, Gregory M, Pien, Gary C, Ivanciu, Lacramioara, Camire, Rodney M, Ertl, Hildegund, Mingozzi, Federico, High, Katherine A, Basner-Tschakarjan, Etiena
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588448/
https://ncbi.nlm.nih.gov/pubmed/26445723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.29
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