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AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes

Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe. Administration to humans, however, revealed that adaptive immu...

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Dades bibliogràfiques
Publicat a:Mol Ther Methods Clin Dev
Autors principals: Hui, Daniel J, Edmonson, Shyrie C, Podsakoff, Gregory M, Pien, Gary C, Ivanciu, Lacramioara, Camire, Rodney M, Ertl, Hildegund, Mingozzi, Federico, High, Katherine A, Basner-Tschakarjan, Etiena
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588448/
https://ncbi.nlm.nih.gov/pubmed/26445723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.29
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