An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8(+) T Cells

Multiple independent adeno-associated virus (AAV) gene therapy clinical trials for hemophilia B, utilizing different AAV serotypes, have reported a vector dose-dependent loss of circulating factor IX (FIX) protein associated with capsid-specific CD8(+) T cell (Cap-CD8) elimination of transduced hepa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Palaschak, Brett, Marsic, Damien, Herzog, Roland W., Zolotukhin, Sergei, Markusic, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415329/
https://ncbi.nlm.nih.gov/pubmed/28480313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.04.004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados