An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8(+) T Cells

Multiple independent adeno-associated virus (AAV) gene therapy clinical trials for hemophilia B, utilizing different AAV serotypes, have reported a vector dose-dependent loss of circulating factor IX (FIX) protein associated with capsid-specific CD8(+) T cell (Cap-CD8) elimination of transduced hepa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Palaschak, Brett, Marsic, Damien, Herzog, Roland W., Zolotukhin, Sergei, Markusic, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415329/
https://ncbi.nlm.nih.gov/pubmed/28480313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.04.004
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