Targeting Hsp90: small-molecule inhibitors and their clinical development

по Taldone, Tony, Gozman, Alexander, Maharaj, Ronnie, Chiosis, Gabriela
Опубликовано 2008

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

по Kang, Yanlong, Taldone, Tony, Patel, Hardik J., Patel, Pallav D., Rodina, Anna, Gozman, Alexander, Maharaj, Ronnie, Clement, Cristina C., Patel, Maulik R., Brodsky, Jeffrey L., Young, Jason C., Chiosis, Gabriela
Опубликовано 2014

Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators

по Ahn, James H., Luo, Wenjie, Kim, Joungnam, Rodina, Anna, Clement, Cristina C., Aguirre, Julia, Sun, Weilin, Kang, Yanlong, Maharaj, Ronnie, Moulick, Kamalika, Zatorska, Danuta, Kokoszka, Malgorzata, Brodsky, Jeffrey L., Chiosis, Gabriela
Опубликовано 2011

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an All...

по Taldone, Tony, Kang, Yanlong, Patel, Hardik J., Patel, Maulik R., Patel, Pallav D., Rodina, Anna, Patel, Yogita, Gozman, Alexander, Maharaj, Ronnie, Clement, Cristina C., Lu, Alvin, Young, Jason C., Chiosis, Gabriela
Опубликовано 2014

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

по Rodina, Anna, Patel, Pallav D., Kang, Yanlong, Patel, Yogita, Baaklini, Imad, Wong, Michael J.H., Taldone, Tony, Yan, Pengrong, Yang, Chenghua, Maharaj, Ronnie, Gozman, Alexander, Patel, Maulik R., Patel, Hardik J., Chirico, William, Erdjument-Bromage, Hediye, Talele, Tanaji T., Young, Jason C., Chiosis, Gabriela
Опубликовано 2013

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

по Rodina, Anna, Taldone, Tony, Kang, Yanlong, Patel, Pallav D., Koren, John, Yan, Pengrong, DaGama Gomes, Erica M., Yang, Chenghua, Patel, Maulik R., Shrestha, Liza, Ochiana, Stefan O., Santarossa, Cristina, Maharaj, Ronnie, Gozman, Alexander, Cox, Marc B., Erdjument-Bromage, Hediye, Hendrickson, Ronald C., Cerchietti, Leandro, Melnick, Ari, Guzman, Monica L., Chiosis, Gabriela
Опубликовано 2014