Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

[Image: see text] The discovery and development of heat shock protein 70 (Hsp70) inhibitors is currently a hot topic in cancer. In the preceding paper in this issue (10.1021/jm401551n), we have described structure–activity relationship studies in the first Hsp70 inhibitor class rationally designed t...

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Detalhes bibliográficos
Main Authors: Taldone, Tony, Kang, Yanlong, Patel, Hardik J., Patel, Maulik R., Patel, Pallav D., Rodina, Anna, Patel, Yogita, Gozman, Alexander, Maharaj, Ronnie, Clement, Cristina C., Lu, Alvin, Young, Jason C., Chiosis, Gabriela
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983364/
https://ncbi.nlm.nih.gov/pubmed/24548239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401552y
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